Background: Seizure is one of the most common symptoms of epilepsy caused by abnormal electrical activity of neurons; Because of the side effects of chemical drugs the use of herbal medicines can be a good alternative to seizure control. In this study the effect of Ferulago angulata (Schlecht) Boisss hydroalcoholic extract was investigated pentylenetetrazole (PTZ) in male mice. In this experimental study, 48 male mice weighing 25-30g were divided into 6groups' saline; positive control group (received diazepam as an anticonvulsant drug of 1 mg/kg) and 4 experimental groups. The negative control group received normal saline and the test groups received doses of 100, 200, 400, 800mg/kg of extract respectively. 30 minutes later pentylenetrazole was injected intraperitoneally with a dose of 85 mg/kg to produce epileptic seizures recorded the seizure behaviors of animals was recorded. Results: Injection of Ferulago angulata hydroalcoholic extract delayed the onset of seizure at 400 dose (P<0.001), and reduced the duration of clonic seizure, which had the highest effect in doses of 200 and 400 mg/kg P<0.01 and P<0.001 respectively. Also, administration of hydroalcoholic extract of Ferulago angulata caused a decrease in the duration of tonic-clonic and decreased the total duration of seizure in animals. Conclusion: In general, intraperitoneal injection of Ferulago hydroalcoholic extract causes delay in attacks in various phases of seizure and it seems the future studies will be necessary to separate its ingredients and understand its mechanism of action.