Effects of aqueous cinnamon extract on body mass index, organs weight and biochemical indices of male Wistar rats on a high-fat diet

Nejatbakhsh, Reza; Ghorbanlou, Mehrdad; Rostamkhani, Somaye; Mahmazi, Sanaz; Bayati, Vahid; Shokri, Saeed

doi:10.22118/jsmj.2014.237155

Effects of aqueous cinnamon extract on body mass index, organs weight and biochemical indices of male Wistar rats on a high-fat diet

Document Type : Original Article

Authors

Reza Nejatbakhsh ¹

mehrdad ghorbanlou ²

somaye rostamkhani ³

Sanaz Mahmazi ⁴

vahid Bayati ⁵

saeed shokri ⁶

¹ Dept. of anatomical sciences, faculty of medicine - Zanjan University of Medical Sciences - Zanjan - Iran

² anatomical sciences, faculty of medicine, Zanjan University of Medical Sciences, Zanjan, Iran

³ Dept. of animal physiology, faculty of basic sciences and medicine, Islamic Azad University of Zanjan - Zanjan - Iran

⁴ Dept. of biology (genetics) - faculty of basic science and medicine - Islamic Azad University of Zanjan - Zanjan - Iran

⁵ Dept. of anatomical sciences - Faculty of medicine - Ahvaz Jundishapur University of Medical Sciences - Ahvaz - Iran

⁶ Dept. of anatomical sciences - Faculty of Medicine - Zanjan Univerity of Medical Sciences - Zanjan - Iran

10.22118/jsmj.2014.237155

Abstract

Background and Objective: Consuming herbal supplements for preventing obesity is cheaper and safer in comparison to chemical drugs. Considering the anti-obesity effect of Cinnamon, in this study, effects of two different doses of aqueous cinnamon extract on weight and biochemical indices related to metabolic syndrome in rat's on a diet of high-fat were investigated.
Method and Materials: Thirty two male Wistar rats were studied in four groups: Control (normal diet), high-fat diet group (high-fat diet with 60% additional fat), 2 high-fat diet groups treated with 100 mg/kg and 200 mg/kg of extract. Treatment was done daily for 20 weeks by gavage. Then, dissection was done and blood samples were taken from the heart. Weights of internal organs and omental fat were measured, and biochemical tests were performed.
Results: One hundred mg/kg dose of extract, reduced BMI and omental fat in comparison to the high-fat diet group. Both doses of extract could reduce leptin level in comparison to the high-fat diet group. Dose of 100 mg/kg prevented the weight reduction of pancreas.
Conclusion: In the present study, anti-obesity effects of 100 mg/kg dose of extract was observed which may be the evidence of positive effects of low doses of extract. Aqueous cinnamon extract can be used as a flavor with meals.
Keywords: obesity, high-fat diet, aqueous cinnamon extract

Keywords

obesity

high-fat diet

aqueous cinnamon extract