Jundishapur Scientific Medical Journal

Jundishapur Scientific Medical Journal

Effect of Cochlear Implantion on Central Auditory Development in Children with Congenital Deafness

Document Type : Original Article

Authors
Arash Bayat 1
Nader Saki 2
Majid Karimi 3
1 Associate Professor, Department of Audiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
2 Professor, Department of Otolaryngology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3 Instructor, Department of Audiology, Iran University of Medical Sciences, Tehran, Iran.
10.22118/jsmj.2025.514582.3864
Abstract
Background and Objectives Cochlear implant (CI) is now the standard treatment option for management of children with profound hearing loss. Cortical auditory evoked potentials (CAEPs) are a non-invasive procedure that can be used to objectively assess the maturation of the auditory cortex in children. The objective of current study was to investigate the effect of CI on central auditory maturation in children through a CAEPs recording.
Subjects and Methods This cross-sectional study involved a total of 78 children with unilateral CI. CAEPs were recorded in CI recipients in response to /s/, /g/ and /m/ speech stimuli. The CAEP responses were recorded before CI (pre-CI), 2-month post-CI, 6-month post-CI, and 12-month post-CI. The latency and wave amplitude of P1 response was recoded for all children.
Results The mean latency of P1 wave was significantly reduced for all speech stimuli after CI compared to pre-CI time-point (P<0.001). Similarly, there was a significant increase in the amplitude of P1 after CI compared to pre-CI condition (P<0.001). Furthermore, comparisons of P1 latency and wave amplitude in response to different speech stimuli revealed that the /g/ stimulus elicited the lowest latency, and the /m/ stimulus evoked the largest amplitude.
Conclusion CAEPs are an objective approach that can be utilized to monitor auditory cortical plasticity in children with congenital deafness after cochlear implantation.
Keywords
Cochlear implant
Cortical auditory evoked potential
Children
Congenital deafness
Subjects
 
[1] Manrique M, Ramos Á, de Paula Vernetta C, Gil-Carcedo E, Lassaletta L, Sanchez-Cuadrado I, Espinosa JM, Batuecas Á, Cenjor C, Lavilla MJ, Núñez F. Guideline on cochlear implants. Acta Otorrinolaringologica (English Edition). 2019 Jan 1;70(1):47-54. [10.1016/j.otorri. 2017.10.007 ] [PMID]
 [2]Gatto A, Tofanelli M, Valentinuz G, Mascherin A, Costariol L, Rizzo S, Borsetto D, Boscolo-Rizzo P, Tirelli G. Cochlear implant cost analysis in adults: a European narrative review. European Archives of Oto-Rhino-Laryngology. 2024 Sep;281(9):4455-71.[ 10.1007/s00405-024-08591-3 ] [PMID]
[3]Pignac S, Sygal N, Biglari M, Olds J, Fitzpatrick EM. Determining cochlear implant candidacy in children with residual hearing: A scoping review. Int J Pediatr Otorhinolaryngol. 2024; 177: 111855. [10.1016/j.ijporl.2024.111855 ] [PMID]
[4]Neukam JD, Kunnath AJ, Patro A, Gifford RH, Haynes DS, Moberly AC, Tamati TN. Barriers to cochlear implant uptake in adults: A scoping review. Otology & Neurotology. 2024 Dec 1;45(10):e679-86. [10.1097/MAO.0000000000004340 ] [PMID]
[5]Leigh J, Dettman S, Dowell R, Briggs R. Communication development in children who receive a cochlear implant by 12 months of age. Otology & neurotology. 2013 Apr 1;34(3):443-50. [10.1097/MAO. 0b013e 318 2814d2c ] [PMID]
 [6]Xiong S, Jiang L, Wang Y, Pan T, Ma F. The role of the P1 latency in auditory and speech performance evaluation in cochlear implanted children. Neural Plasticity. 2022;2022(1):6894794[10.1155/2022/6894794] PMID]
[7]Stuermer KJ, Foerst A, Sandmann P, Fuerstenberg D, Lang-Roth R, Walger M. Maturation of auditory brainstem responses in young children with congenital monaural atresia. International Journal of Pediatric Otorhinolaryngology. 2017 Apr 1;95:39-44. [10.1016/j. ijporl.2017.01.029 ] [PMID]
[8]Kral A, Sharma A. Crossmodal plasticity in hearing loss. Trends in Neurosciences. 2023 May 1;46(5):377-93. [10.1016/j.tins.2023.02.004 ] [PMID]
[9]Pavani F, Bottari D. Neuroplasticity following cochlear implants. Handbook of clinical neurology. 2022 Jan 1;187:89-108. [10.1016/B978-0-12-823493-8.00016-X ] [PMID]
[10]Bell-Souder D, Chen C, Spahr A, Sharma A. Validation of direct recording of electrically evoked cortical auditory evoked potentials through a cochlear implant system. Scientific Reports. 2024 Nov 17;14(1):28366. [10.1038/s41598-024-79528-3 ] [PMID]
[11]Visram AS, Innes-Brown H, El-Deredy W, McKay CM. Cortical auditory evoked potentials as an objective measure of behavioral thresholds in cochlear implant users. Hearing research. 2015 Sep 1;327:35-42. [10.1016/j.heares.2015.04.012 ] [PMID]
[12]DeFreese AJ, Lindquist NR, Shi L, Holder JT, Berg KA, Haynes DS, Gifford RH. The impact of daily processor use on adult cochlear implant outcomes: Reexamining the roles of duration of deafness and age at implantation. Otology & Neurotology. 2023 Aug 1;44(7):672-8. [10.1097/MAO.0000000000003920] [PMID]
[13]Tavora-Vieira D, Ffoulkes E. Direct elicitation of cortical auditory evoked potentials by electrical stimulation and their use to verify the most comfortable level of stimulation in cochlear implant users. Audiology and Neurotology. 2023 Aug 2;28(4):294-307. [10.1159/0005 29797 ] [PMID]
[14]Távora-Vieira D, Wedekind A, Ffoulkes E, Voola M, Marino R. Cortical auditory evoked potential in cochlear implant users: an objective method to improve speech perception. PLoS One. 2022 Oct 7;17(10):e0274643. [10.1371/journal.pone.0274643 ] [PMID]
[15]Sharma A, Dorman MF, Kral A. The influence of a sensitive period on central auditory development in children with unilateral and bilateral cochlear implants. Hearing research. 2005 May 1;203(1-2):134-43. [10.1016/j.heares.2004.12.010 ] [PMID]
[16]Eskicioğlu E, Kirkim G, Gürkan S, Durankaya SM, Başokçu TO, Güneri EA. Changes in P1 latencies of children with normal hearing and those with cochlear implants. Turkish Journal of Medical Sciences. 2020;50(4):1062-8. [10.3906/sag-1910-233 ] [PMID]
[17]Attias J, HabibAllah S, Tarigoppula VS, Glick H, Chen C, Kanthaiah K, Litvak L. Cortical auditory evoked potentials recorded directly through the cochlear implant in cochlear implant recipients: A feasibility study. Ear and Hearing. 2022 Sep 1;43(5):1426-36. [10.1097/AUD.0000000000001212 ] [PMID]
[18]Wedekind A, Távora-Vieira D, Rajan GP. Cortical auditory evoked responses in cochlear implant users with early-onset single-sided deafness: indicators of the development of bilateral auditory pathways. Neuroreport. 2018 Mar 21;29(5):408-16. [10.1097/ WNR.0000000000000984 ] [PMID]
[19]Han JH, Lee HJ, Kang H, Oh SH, Lee DS. Brain plasticity can predict the cochlear implant outcome in adult-onset deafness. Frontiers in Human Neuroscience. 2019 Feb 19;13:38. [10.3389/fnhum.2019.00038 ] [PMID]
[20]Glennon E, Svirsky MA, Froemke RC. Auditory cortical plasticity in cochlear implant users. Current opinion in neurobiology. 2020 Feb 1;60:108-14. [10.1016/ j.conb.2019.11.003 ] [PMID]
[21]Sharma A, Dorman MF, Kral A. The influence of a sensitive period on central auditory development in children with unilateral and bilateral cochlear implants. Hearing research. 2005 May 1;203(1-2):134-43. [10.1016/j.heares.2004.12.010 ] [PMID]
[22]Costa I, D'Agostini AR, Sousa JA, Souza AP, Biaggio EP. Cortical auditory evoked potentials in 2-year-old subjects. International Archives of Otorhinolaryngology. 2020 Aug 28;24(3):282-7. [10. 1055/s-0039-1700585 ] [PMID]
 
 
Authors retain the copyright and full publishing rights.
Published by ahvaz jundishapur university of medical science. This article is an open access article licensed under the Creative Commons Attribution-NonCommercial 4.0 (https://creativecommons.org/licenses/by-nc/4.0/).
 
 [23]Beynon AJ, Luijten BM, Mylanus EA. Intracorporeal cortical telemetry as a step to automatic closed-loop EEG-based CI fitting: A proof of concept. Audiology Research. 2021 Dec 13;11(4):691-705. [10.3390/ audiolres11040062 ] [PMID]
[24]Jacobson GP, Lombardi DM, Gibbens ND, Ahmad BK, Newman CW. The effects of stimulus frequency and recording site on the amplitude and latency of multichannel cortical auditory evoked potential (CAEP) component N1. Ear and hearing. 1992 Oct 1;13(5):300-6. [10.1097/00003446-199210000-00007 ] [PMID]
 
 
 

  • Receive Date 31 March 2025
  • Revise Date 09 May 2025
  • Accept Date 11 May 2025