Jundishapur Scientific Medical Journal

Jundishapur Scientific Medical Journal

The Effect of Twelve Weeks of Resistance Training and Creatine Hydrochloride Supplementation on Blood Oxygen Levels and Fatigue in Cognitive Activities of Middle-Aged Men

Document Type : Original Article

Authors
1 PhD Student, Department of Physical Education and Sport Sciences, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran.
2 Assistance professor, Department of Physical Education and Sport Sciences, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran.
10.32592/jsmj.23.6.521
Abstract
Background and Objectives Cognitive performance is influenced by health-related factors such as physical fitness and nutrition, as well as cognitive exercises such as brain games. The aim of the present study was to investigate the effect of twelve weeks of resistance training and creatine hydrochloride supplementation on blood oxygen levels and fatigue in cognitive activities of middle-aged men.
Subjects and Methods In the present quasi-experimental study, 36 middle-aged men were randomly divided into three groups: resistance training + supplement (n = 12), resistance training + placebo (n = 12), and control group (n = 12). Resistance training was completed for 12 weeks with a frequency of four sessions per week and an intensity of 70 to 85% of one repetition maximum. Also, in the supplement group, creatine hydrochloride was consumed at a rate of three grams per day. Fatigue and arterial oxygen were measured in two stages: pre-test and post-test, before and after the Mafia game.
Results A significant decrease in fatigue was observed in the resistance training + supplement groups (P < 0.001) and resistance training + placebo (P < 0.001) compared to the control group. The results of blood oxygen levels between the groups in the first and second stages did not show a significant difference (P > 0.05).
Conclusion A period of resistance training significantly improved fatigue without affecting arterial oxygen levels, but supplementation had no significant effect on fatigue and arterial oxygen.
Keywords
Subjects

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    • Wrigglesworth J, Yaacob N, Ward P, Woods RL, McNeil J, Storey E, et al. Brain-predicted age difference is associated with cognitive processing in later-life. Neurobiology of Aging. 2022;109:195-203.[ 1016/j.neurobiolaging.2021.10.007 ] [PMID]
    • Brioschi Guevara A, Bieler M, Altomare D, Berthier M, Csajka C, Dautricourt S, Démonet JF, Dodich A, Frisoni GB, Miniussi C, Molinuevo JL. Protocols for cognitive enhancement. A user manual for Brain Health Services—part 5 of 6. Alzheimer's Research & Therapy. 2021 Dec;13:1-3. [1186/s13195-021-00844-1 ][PMID]
    • Dana A, Fallah Z, Moradi J, Ghalavand A. The effect of cognitive and aerobic training on cognitive and motor function, and brain-derived neurotrophic factors in elderly men. Journal of Sports and Motor Development and Learning. 2019;10(4):537-52.
    • Stillman CM, Esteban-Cornejo I, Brown B, Bender CM, Erickson KI. Effects of exercise on brain and cognition across age groups and health states. Trends in neurosciences. 2020 Jul 1;43(7):533-43. [1016/j.tins.2020.04.010 ][PMID]
    • Cox EP, O’Dwyer N, Cook R, Vetter M, Cheng HL, Rooney K, O’Connor H. Relationship between physical activity and cognitive function in apparently healthy young to middle-aged adults: A systematic review. Journal of science and medicine in sport. 2016 Aug 1;19(8):616-28. [1016/j.jsams.2015.09.003 ][PMID]
    • Targum SD, Fava M, Alphs LD, Lynn Starr H, Wessel TC, Hilt DC. Fatigue across the CNS spectrum: a clinical review. Fatigue: Biomedicine, Health & Behavior. 2014 Oct 2;2(4):231-46.
    • Nybo L, Rasmussen P. Inadequate cerebral oxygen delivery and central fatigue during strenuous exercise. Exercise and sport sciences reviews. 2007 Jul 1;35(3):110-8. [1097/jes.0b013e3180a031ec ][PMID]
    • Scholey AB, Moss MC, Neave N, Wesnes K. Cognitive performance, hyperoxia, and heart rate following oxygen administration in healthy young adults. Physiology & behavior. 1999 Nov 1;67(5):783-9. [1016/s0031-9384(99)00183-3 ][PMID]
    • Jafari M, GHALAVAND A, RAJABI H, KHALEDI N, MOTAMEDI P. A review of the effect of exercise training on neuromuscular junction in throughout life: A logical analysis of animal experimental studies. 2021.
    • Zabihi Rezaei Z, Motamedi P, Ghalavand A. The effect of circuit resistance training on body composition and physical function in patients with Parkinson's disease. Journal of Jiroft University of Medical Sciences. 2022 Aug 10;9(2):949-57.
    • Voss MW, Nagamatsu LS, Liu-Ambrose T, Kramer AF. Exercise, brain, and cognition across the life span. Journal of applied physiology. 2011 Nov;111(5):1505-13. [1152/japplphysiol.00210.2011 ][PMID]
    • Li Z, Peng X, Xiang W, Han J, Li K. The effect of resistance training on cognitive function in the older adults: a systematic review of randomized clinical trials. Aging Clinical and Experimental Research. 2018 Nov;30:1259-73. [1007/s40520-018-0998-6 ][PMID]
    • Chen HR, Zhang-Brotzge X, Morozov YM, Li Y, Wang S, Zhang HH, Kuan IS, Fugate EM, Mao H, Sun YY, Rakic P. Creatine transporter deficiency impairs stress adaptation and brain energetics homeostasis. JCI insight. 2021 Sep 9;6(17). [1172/jci.insight.140173 ][PMID]
    • Hall M, Trojian TH. Creatine supplementation. Current sports medicine reports. 2013 Jul 1;12(4):240-4. [1249/JSR.0b013e31829cdff2 ][PMID]
    • Roschel H, Gualano B, Ostojic SM, Rawson ES. Creatine supplementation and brain health. Nutrients. 2021 Feb 10;13(2):586. [3390/nu13020586 ][PMID]
    • Tayebi M, Arazi H. Is creatine hydrochloride better than creatine monohydrate for the improvement of physical performance and hormonal changes in young trained men?. Science & Sports. 2020 Oct 1;35(5):e135-41.
    • van Balkom TD, van den Heuvel OA, Berendse HW, van der Werf YD, Vriend C. The effects of cognitive training on brain network activity and connectivity in aging and neurodegenerative diseases: a systematic review. Neuropsychology Review. 2020 Jun;30(2):267-86. [1007/s11065-020-09440-w ][PMID]
    • Vermeir JF, White MJ, Johnson D, Crombez G, Van Ryckeghem DM. The effects of gamification on computerized cognitive training: systematic review and meta-analysis. JMIR serious games. 2020 Aug 10;8(3):e18644. [2196/18644 ][PMID]
    • Smid CR, Karbach J, Steinbeis N. Toward a science of effective cognitive training. Current Directions in Psychological Science. 2020 Dec;29(6):531-7.
    • Kim M, Kim S. Generative AI in Mafia-like Game Simulation. arXiv preprint arXiv:2309.11672. 2023 Sep 20.
    • Amann M, Calbet JA. Convective oxygen transport and fatigue. Journal of applied physiology. 2008 Mar;104(3):861-70. [1152/japplphysiol.01008.2007 ][PMID]
    • Brzycki M. Strength testing—predicting a one-rep max from reps-to-fatigue. Journal of physical education, recreation & dance. 1993 Jan 1;64(1):88-90.
    • Martín-Escudero P, Cabanas AM, Fuentes-Ferrer M, Galindo-Canales M. Oxygen saturation behavior by pulse oximetry in female athletes: breaking myths. Biosensors. 2021;11(10):391. Martín-Escudero P, Cabanas AM, Fuentes-Ferrer M, Galindo-Canales M. Oxygen saturation behavior by pulse oximetry in female athletes: breaking myths. Biosensors. 2021 Oct 14;11(10):391. [3390/bios11100391 ][PMID]
    • Smets EM, Garssen B, Bonke BD, De Haes JC. The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. Journal of psychosomatic research. 1995 Apr 1;39(3):315-25. [1016/0022-3999(94)00125-o ][PMID]
    • Rawson ES, Dolan E, Saunders B, Williams ME, Gualano B. Creatine supplementation in sport, exercise and health. InDietary supplementation in sport and exercise 2019 Jun 7 (pp. 141-164). Routledge.
    • Leavitt VM, DeLuca J. Central fatigue: issues related to cognition, mood and behavior, and psychiatric diagnoses. PM&R. 2010 May 1;2(5):332-7. [1016/j.pmrj.2010.03.027 ][PMID]
    • Sun H, Soh KG, Mohammadi A, Toumi Z, Zhang L, Ding C, Gao X, Tian J. Counteracting mental fatigue for athletes: a systematic review of the interventions. BMC psychology. 2024 Feb 9;12(1):67. [1186/s40359-023-01476-w ][PMID]
    • Herold F, Törpel A, Schega L, Müller NG. Functional and/or structural brain changes in response to resistance exercises and resistance training lead to cognitive improvements–a systematic review. European Review of Aging and Physical Activity. 2019 Dec;16:1-33.
    • Chow ZS, Moreland AT, Macpherson H, Teo WP. The central mechanisms of resistance training and its effects on cognitive function. Sports Medicine. 2021 Dec;51(12):2483-506. [1007/s40279-021-01535-5 ][PMID]
Volume 23, Issue 6 - Serial Number 153
January and February 2025
Pages 521-534

  • Receive Date 16 November 2024
  • Revise Date 30 November 2024
  • Accept Date 03 December 2024