Jundishapur Scientific Medical Journal

Jundishapur Scientific Medical Journal

Oral Complications in Patients Receiving Radiotherapy in the Head and Neck Region with or without Chemotherapy Refering to Milad Hospital from 2020-2021

Document Type : Original Article

Authors
Forooz Keshani 1
Alireza Amouheidari 2
Amin Davoodi 3
Ali Goodarzi 4
Neda Kargahi 5
1 Dental Research Center, Department of Oral and Maxillofacial Pathology, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
2 Isfahan Milad Hospital , Deputy Manager in Research & Education, Head, Department of Radiation Oncology , Isfaha,Iran
3 Department of Oral and Maxillofacial Pathology ,Students Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
4 Department of Oral and Maxillofacial Pathology ,Students Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran orcid: 0000-0003-0029-3045
5 Department of Oral and Maxillofacial Pathology ,Students Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
10.32592/JSMJ.23.4.313
Abstract
Background and Objectives Oral complications can significantly impact not only the treatment process of patients undergoing chemotherapy and radiotherapy but also their overall quality of life. This study aimed to evaluate the frequency of oral complications in patients undergoing radiotherapy with or without chemotherapy in Milad Hospital of Isfahan in 2020-2021.
Subjects and Methods This descriptive and analytical study was conducted on 43 patients diagnosed with cancer who were admitted to the chemotherapy and radiotherapy department at Milad Hospital. Two dental students examined the patients for oral lesions and complications. The data were recorded in SPSS and analyzed using Spearman's correlation, Fisher's exact test, Mann-Whitney U test, Kruskal-Wallis test, and the t-test (p-value < 0.05).
Results Among the 43 patients, the most common oral lesions included mucositis, xerostomia, taste dysfunction and dysphasia. Statistically significant correlations were found between mucosal hemorrhage and cancer site, oropharyngeal ulcer and average radiotherapy dose, mucositis grade and average radiotherapy dose, xerostomia and average radiotherapy dose, and nausea and average radiotherapy dose. However, no significant relationships were observed between other factors and the study variables.
Conclusion The intensity of some complications caused by radiotherapy on oral mucosa, including mucositis, xerostomia, oropharynx ulcer and neusa in patients, increased with higher radiations doses. Therefore, clinicians can potentially manage oral complications more effectively by implementing various strategies, including carefully controlling radiotherapy doses and providing comprehensive oral hygiene education to patien               
Keywords
Complications
Head and neck neoplasms
Radiotherapy
Chemotherapy
Subjects

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Jundishapur Scientific Medical Journal
Volume 23, Issue 4 - Serial Number 151
September and October 2024
Pages 313-322

  • Receive Date 08 April 2024
  • Revise Date 13 June 2024
  • Accept Date 16 June 2024