Jundishapur Journal of Medical Sciences

Jundishapur Journal of Medical Sciences

Clinicopathological Characteristics and Survival of Head and Neck Non-Hodgkin Lymphomas: A Retrospective Study at Shahid Sadoughi Hospital, Yazd, Iran

Document Type : Original Article

Authors
Mahlagha Zahedi 1
Sadra Nasr 2
1 Assistant Professor of Pathology, Department of Pathology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2 General Physician, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
10.22118/jsmj.2026.574024.4137
Abstract
Background : Non-Hodgkin lymphomas are among the most common malignancies of the lymphatic system and may initially present with head and neck manifestations. This study aimed to investigate the clinicopathological features and survival of patients with head and neck non-Hodgkin lymphomas .

Methods: This was a retrospective descriptive-analytical survival study. All patients with head and neck non-Hodgkin lymphomas whose pathological specimens were examined at the pathology department of Shahid Sadoughi Hospital in Yazd between 2011 and 2020 were included.

Findings: A total of 55 patients were included in the study. The most common pathological type was Diffuse large B cell lymphoma, with a frequency of 76.4%. The most frequent clinical manifestation was a neck mass (63.6%), and the most common site of involvement was the neck. The highest mean age was observed in patients with T-cell lymphomas, while the lowest mean age was seen in Burkitt lymphoma; this difference was statistically significant (P=0.001). The type of treatment showed a significant association with the pathological type (P=0.001). At the end of the follow-up period, 32.7% of the patients had died, and the mean survival time was 79.5 months.

Conclusion: Diffuse large B cell lymphoma is the most common type of head and neck non-Hodgkin lymphoma among the studied patients. Clinicopathological features, treatment type, and pathological subtype significantly affect survival. Understanding these patterns can contribute to improving diagnostic and therapeutic decision-making for patients with head and neck non-Hodgkin lymphomas.
Keywords
Clinicopathological characteristics
Head and neck
Non-Hodgkin lymphoma
Survival
Subjects
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Jundishapur Journal of Medical Sciences
Volume 25, Issue 3 - Serial Number 162
September and October 2026
Pages 238-248

  • Receive Date 05 February 2026
  • Revise Date 01 June 2026
  • Accept Date 02 June 2026