Study of CD10 immunohistochemical marker expression in prostate cancer and its association with some clinicopathologic markers

Document Type : Original Article

Authors

1 Department Pathology, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran

2 Department of Pathology, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran.

Abstract

Background: The present study was designed to evaluate the frequency of natural endopeptidase (NEP) or CD10 in prostate carcinoma cells in order to evaluate its association with tumor prognostic findings.
Materials and Methods: In this cross-sectional descriptive study, tissue samples of patients referred to Imam Khomeini, Shahid Baqaei and Golestan hospitals of Ahwaz with the diagnosis of prostate adenocarcinoma and benign prostatic hyperplasia were used. Clinical and demographic data of patients were extracted from hospital records.. Anti CD10 monoclonal antibody was used for immunohistochemical staining.
Results: In this study, 51 prostate samples (41 malignant and 10 benign) were studied. The mean age of the patients was 68.4 years, ranging from 40 to 92 years. Stage of cancer was organ confined in the majority of cases (75%). The pattern of expression, expression intensity and staining intensity in malignant specimens were significantly different than benign tissues. CD10 expression decreased in more than 50% of malignant cases. Also, the staining intensity of this marker was significantly lower in malignant samples. In addition, evaluation of correlation between staining intensity with other studied variables showed that there was a significant relationship between staining intensity and gleason score (p <0.0001).
Conclusion: Overall, the findings of the present study indicate that expression of the CD10 marker in malignant prostate tumors is decreased or abolished. However, this marker is expressed in advanced stages of the tumor and is related to the invasive pattern of the tumor.

Keywords

References

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Jundishapur Scientific Medical Journal
Volume 18, Issue 6 - Serial Number 123
March and April 2020
Pages 663-672

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History

  • Receive Date: 05 January 2020
  • Revise Date: 12 February 2020
  • Accept Date: 19 February 2020

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