Evaluation of Antifungal effect of Alum on the growth of Candida albicans and Candida Tropicalis Growth in Laboratory study

Document Type : Original Article

Authors

1 Assisstance Professor of Oral and Maxillofacial Medicine, Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

2 assistance professor of oral and Maxillofacial Medicine,faculty of Dentistry,Ahvaz jundishapur University of Medical Sciences,Ahvaz,Iran.

3 assistance professor of Microbiology,faculty of Medicine,Ahvaz jundishapur University of Medical Sciences,Ahvaz,Iran.

4 faculty of Dentistry,Ahvaz jundishapur University of Medical Sciences,Ahvaz,Iran.

Abstract

Aim: Candida albicans and Candida tropicalis are the most etiologic factors in the diseases caused by yeast species.Considering the increased resistance of fungi to some antifungal drugs and many of these drugs are toxic and expensive, the study of natural products on these fungi is necessary.Therefore, the aim of this study was to investigate the effect of white alum (Alum) on the prevention of Candida albicans and Candida tropicalis in vitro conditions.Methods: In this laboratory study,using modified E. test method, white alum solutions were prepared at concentrations of(8, 4 , 2, 1, 0.5, 0.25 and 0.125 mg/100ml) then10 μLof each dilution Poured in blank disks that placed linearly on the culture medium inoculated with the fungus, then for 24 hours due to the low growth rate of these fungi, the petri was incubated at 37 ° C, and the minimum growth inhibitory concentration (MIC) was obtained. It should be noted that the test was repeated three times and averaged.Results: The findings of this study showed that white alum has a positive effect on inhibiting the growth of Candida albicans and Candida tropicalis colonies. MIC for Candida albicans and Candida capillaries was 0.13 and 0.06 mg / ml, respectively.Conclusion: the use of white alum can be a good cure in the treatment of Candida albicans and Candida tropicalis infection in dental treatment.

Keywords

References

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Jundishapur Scientific Medical Journal
Volume 18, Issue 4 - Serial Number 121
November and December 2019
Pages 403-414

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History

  • Receive Date: 06 July 2019
  • Revise Date: 30 September 2019
  • Accept Date: 12 October 2019

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