Has Coronary Artery Disease in Young Patients Referred to the University Hospital Increased?

Document Type : Original Article

Authors

1 Department of Cardiology, Atherosclerosis Center (Cardiovasclar, Disease Research Center), Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

2 Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Abstract

Background and Objective: Coronary artery disease (CAD) is the major cause of deaths and injuries in the world, including Iran and higher percentage of deaths occur in young people. The purpose of this study was to evaluate the prevalence of coronary artery disease in the past decade among young people referring to the hospital.
Subjects and Methods: This cross-sectional epidemiological study was based on data collected from patients records admitted for elective angiography Ahvaz Golestan Hospital from 2001 to 2011. The patients were divided into 5 age groups. Each group wasallocated according to number and severity of CAD, into five groups; normal (without conflicts), minimal (conflicts below 50 %), one, two and three vessels stenosis. Severity of coronary artery disease in each age group were compared with ten years later.
Results: The overall CAD prevalence was 67.6% in 2001 and 65.3% in 2011 (P<0.54). In 2001, the prevalence of coronary artery disease in five groups (equal and younger than 45, 46-50, 51-55, 56-60, and elder than 60year-old) were 52.45, 68.1, 66.6, 71.1, 83.3 percent, respectively; and in 2011, 42.2, 56.25%, 60%, 69.5% and 79.4 percent, respectively. (P-values were respectively: 0.29, 0.19, 0.48, 0.85 and 0.57).
Conclusion: The overall prevalence of coronary artery disease among different age groups did not change significantly over time. It seems that there is no significant change in frequency of CAD between 2001 and 2011 years in this study

Keywords


-Ebrahimi M, Kazemi-Bajestani SMR, Ghayour-Mobarhan M, Ferns GAA. The status of coronary Artery Disease and Its risk factors in Iran: A review. IRCMJ 2011 Sep; 13(9): 615-626.
2-Hatmi ZN, Tahvildari S,  Gafarzadeh Motlag A, Sabouri Kashani A. Prevalence of coronary artery disease risk factors in Iran: a population based survey. BMC  Cardiovasc Disord 2007 Oct; 7(32): 1-5.
3-Fuster V, Kelly BB. Promoting Cardiovascular Health in the Developing World: A Critical Challenge to Achieve Global Health.Institute of Medicine (US) Committee on Preventing the Global Epidemic of Cardiovascular Disease: Meeting the Challenges in Developing Countries. Washington: National Academies P Bookshelf ID: NBK45688.
4-Castelli WP, Epidemiology of coronary heart disease: the Framingham study. Am J Med 1984 ; 76(2A): 4-12.
5-Gaziano TA. Global burden of cardiovascular disease. In: Bonow R, Mann D, Zipes D. Braunwald's Heart Disease. 9th ed. Philadelphia: Saunder publisher; 2012: 5-18.
6-Enbergs A, Burger R, Reinecke H,Borggrefe M ,Breithardt G and Kerber S. Prevalence of coronary artery disease in general population without suspicion of coronary artery disease. Eur Heart J 2000; 21(1): 45-52.
7-Chaitman BR, Bourassa MG, Davis K, Rogers WJ, Tyras DH, Berger R. Angiographic prevalence of high-risk coronary artery disease. Circulation 2004; 64(2): 360-7.
8-Lopez AD, Mathers CD, Ezzati M. Global Burden of Disease and risk factors. New York: World Bank group;2006. P. 552.
9-Nozari Y,Hashemlu A,Hatami ZN,Sheikhvatan M,Iravani A,Bazdar A,et al.outcome of coronary artery bypass grafting in patients without major risk factors and patients with at least one major risk factor for coronary artery disease. Indian J Med Sci 2007; 61(10): 547-54.
10-Sarraf-Zadegan N, Sayed-Tabatabaei FA, Bashardoost N, Maleki A, Totonchi M, Habibi HR, ‘et al’.The prevalence of coronary artery disease in an urban population in Isfahan, Iran. Acta Cardiol 1999; 54(5): 257-63.
11-Sadeghi M,Ruhafza H,Shirani S,Akhavan Tabib A,Aghdak P,Hosseini S. The prevalence of coronary artery disease according to rose questionnaire and ecg: Isfahan healthy heart program(IHHP). ARYA Atherosclerosis 2010; 2(2).
12-Fakhrzadeh H,Bandarian F,Adibi H,Samavat T,Malekafzali H,Hodjatzadeh E, ‘et al’. Coronary heart disease and associated risk factors in Qazvin: a population –based study. East Mediterr Health j 2008 ; 14(1): 33-41.
13-Hadaegh F, Harati H, Ghanbarian A, Azizi F. Prevalence of coronary heart disease among Tehran adults: Tehran Lipid and Glucose study. East Mediterr Health J 2009; 15(1): 157-66.
14-Vahdat K, Jafari SM, Pazoki R, Nabipour I. Concurrent increased high sensitivity C-reactive protein and chronic infections are associated with coronary artery disease: a population-based study. Indian J Med Sci 2007; 61: 135-43.
15-Rezaei Ghaleh N, Ghanbarian A, Etemadi A, Momenan AA, Shafiei G, Azizi F. The concordance between Rose angina and ECG-defined CHD in an Iranian urban population: Tehran Lipid and Glucose study. Iran J Endocrin&Metab 2004; 5: 445-437.
16-Pourghadamyari H, Moohebati M, Parizadeh SM, Falsoleiman H, Dehghani M, Fazlinezhad A, ‘et al’. Serum antibody titers against heat shock protein 27 are associated with the severity of coronary artery disease. Cell stress chaperones 2011; 16(3): 309-16.
17-Amani R, Noorizadeh M, Rahmanian S, Afzali N, Haghighizadeh MH. Nutrtional related cardiovascular risk factors in patients with coronary artery disease in Iran: a case –control study. Nutr J 2010;9:70.
18-Ebrahimi M,Kazemi-Bajestani SM,Ghayour-Mobarhan M,Moohebati M,Paydar R,AzimiNezhad M,et al.Metabolic syndrome may not be a good predictor of coronary artety Disease in the Iranian population:population-specific definitions are required . ScientificWorldJournal .2009;9:86-96.
19-Kazemi-Bajestani SM,Ghayour-Mobarhan M,Ebrahimi M,Moohebati M,Esmaili HA,Parizadeh MR ,et al. Serum copper and zinc concentrations are lower in Iranian patients with angiographically defined coronary artery disease than in subjects with a normal angiogram. Jtrace Elem med Biol.2007;21(1):22-80.
20-Nezhad MA,Ghayour-mobarhan M,Parizadeh SM,Safarian M,Esmaeili H,Khodaei GH,et al.Metabolic syndrome:its prevalence and relationship to socio-economic parameters in an Iranian population. Nutr metab cardiovasc dis.2008;18(3): 11-20.
21-Kazemi-Bajestani SM, Ghayour-Mobarhan M, Ebrahimi M, Moohebati  M, Esmaeili HA, Ferns GA.C-reactive protein associated with angiographically defined coronary artery disease. Clin lab 2007; 53(1,2): 49-56.
22-Ghayour-Mobarhan M, Sahebkar A, Parizadeh SM, Moohebati M, Tavallaie S, Rezakazemi-Bajestani SM, ‘et al’. Antibody titres to heat shock protein 27 are elevated in patients with acute coronary syndrome. Int J Exp pathol 2008 Jun; 89(3): 209-15.
23-Parizadeh SM, Moohebati  M, Ghafoori F, Ghayour-Mobarhan M, Kazemi-Bajestani SM, Tavallaie S, ‘et al’. Serum selenium and glutathione peroxidase concentrations in Iranian patients with angiography-defined coronary artery disease. Angiology 2009 May-Apr; 60(2): 186-91.
24-Alamdari DH, Ghayour-Mobarhan M, Tavallaie S, Parizadeh MR, Moohebati M, Ghafoori F, ‘et al’. Prooxidant-antioxidant balance as a new risk factor in patients with angiographically defined coronary artery disease. Clin Biochem 2008 Dec; 41(6): 375-80.