Effect of Grape seed (Grapex) on activity and severity in patients with Rheumatoid Arthritis

Document Type : Original Article

Authors

1 1. Department of Reumatology, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran

2 Department of Reumatology, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran

Abstract

Introduction
Rheumatoid arthritis is a chronic autoimmune disease that characterized by inflammation of peripheral joints, pain, swelling and bone losses. Foods containing flavinoid such as grape seed can reduce pain, inflammation and joint swelling in RA patients. The aim of this study was to evaluate the effect of Grapex on disease severity and activity in RA patients.
Method
Sixty RA patients over the age of 18 years and diagnosed on the basis of ACR criteria are divided into two groups. The first group received 100 mg daily Grapex and the second group received placebo. At the end of the study, after 8 weeks, disease activity Score (DAS28), CRP and ESR were compared based on mean difference in both groups.
Results:
The results showed that DAS28 level was lower in the intervention group after the administration of Grapex that was statistically significant (P <0.001). Whereas in the placebo group the mean DAS28 did not change after and before placebo (P> 0.05).
Conclusion
Regarding significantly change in mean difference of DAS28 that only seen in the intervention group, it can be concluded that Grapex in RA patients decreases the severity of the disease. Therefore, Grapex as a supplement can be a promising treatment to reduce the severity of inflammation in these patients, along with other conventional treatments.

Keywords

References

1-Seif F, Khoshmirsafa M, Mousavi M, Beshkar P, Rafeian-Kopaei M, Bagheri N, et al. Interleukin-21 receptor might be a novel therapeutic target for the treatment of rheumatoid arthritis. Journal of Experimental & Clinical Medicine. 2014;6(2):57-61.
2-Kordasiabi MC, Akhlaghi M, Baghianimoghadam MH, Morowatisharifabad MA, Askarishahi M, Enjezab B, et al. Self Management Behaviors in Rheumatoid Arthritis Patients and Associated Factors in Tehran 2013. Global Journal of Health Science. 2016;8(3):156.
3-Almeida MdSTM, Almeida JVM, Bertolo MB. Demographic and clinical features of patients with rheumatoid arthritis in Piauí, Brazil–evaluation of 98 patients. Revista Brasileira de Reumatologia (English Edition). 2014;54(5):360-5.
4-Da Mota L, Cruz BA, Brenol CV, Pereira IA, Fronza L, Bertolo MB, et al. 2011 Consensus of the Brazilian Society of Rheumatology for diagnosis and early assessment of rheumatoid arthritis. Rev Bras Reumatol. 2011;51(3):199-219.
5-Mok CC. Morning Stiffness in Elderly Patients with Rheumatoid Arthritis: What is Known About the Effect of Biological and Targeted Agents? Drugs & aging. 2018;35(6):477-83.
6-Orange DE, Blachere NE, DiCarlo EF, Mirza S, Pannellini T, Jiang CS, et al. Rheumatoid arthritis morning stiffness is associated with synovial fibrin and neutrophils. Arthritis & Rheumatology. 2019.
7-Nassiri‐Asl M, Hosseinzadeh H. Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2009;23(9):1197-204.
8-Shi J, Yu J, Pohorly JE, Kakuda Y. Polyphenolics in grape seeds—biochemistry and functionality. Journal of medicinal food. 2003;6(4):291-9.
9-Jhun JY, Moon S-J, Yoon BY, Byun JK, Kim EK, Yang EJ, et al. Grape seed proanthocyanidin extract–mediated regulation of STAT3 proteins contributes to treg differentiation and attenuates inflammation in a murine model of obesity-associated arthritis. PLoS One. 2013;8(11).
10-Van Vugt RM, Rijken PJ, Rietveld AG, Van Vugt AC, Dijkmans BA. Antioxidant intervention in rheumatoid arthritis: results of an open pilot study. Clinical rheumatology. 2008;27(6):771-5.
11-Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 1997;275(5297):218-20.
12-Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham III CO, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis & Rheumatism. 2010;62(9):2569-81.
13-Smolen JS, Aletaha D. The assessment of disease activity in rheumatoid arthritis. Clinical & Experimental Rheumatology. 2010;28(3):S18.
14-Li W-G, Zhang X-Y, Wu Y-j, Tian X. Anti-inflammatory effect and mechanism of proanthocyanidins from grape seeds. Acta Pharmacologica Sinica. 2001;22(12):1117-20.
15-Hemmati AA, NAZARI Z, HASANVAND N, AGHEL N, MOHAMMADIAN B. Protective effect of grape seed extract against the fibrogenic effect of bleomycin in rat lung. 2006.
16-Ahmad SF, Zoheir KM, Abdel-Hamied HE, Ashour AE, Bakheet SA, Attia SM, et al. Grape seed proanthocyanidin extract has potent anti-arthritic effects on collagen-induced arthritis by modifying the T cell balance. International Immunopharmacology. 2013;17(1):79-87.
17-Terra X, Montagut G, Bustos M, Llopiz N, Ardèvol A, Bladé C, et al. Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet. The Journal of nutritional biochemistry. 2009;20(3):210-8.
18-Cho M-L, Heo Y-J, Park M-K, Oh H-J, Park J-S, Woo Y-J, et al. Grape seed proanthocyanidin extract (GSPE) attenuates collagen-induced arthritis. Immunology letters. 2009;124(2):102-10.
19-Han HM, Hong SH, Park HS, Jung JC, Kim JS, Lee YT, et al. Protective effects of Fructus sophorae extract on collagen-induced arthritis in BALB/c mice. Experimental and therapeutic medicine. 2017;13(1):146-54.
Jundishapur Scientific Medical Journal
Volume 19, Issue 4 - Serial Number 127
September and October 2020
Pages 383-390

Files

History

  • Receive Date: 30 January 2020
  • Revise Date: 08 August 2020
  • Accept Date: 16 August 2020

Share

How to cite

Statistics