بررسی تاثیر 6 هفته تمرین هوازی تداومی بر سطوح مقاومت به انسولین، نیتریک اکساید و برخی از پروفایل های لیپیدی موش های نر دیابتی ویستار

نوع مقاله: مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری فیزیولوژی ورزشی-قلب و عروق و تنفس، دانشکده تربیت بدنی دانشگاه خوارزمی تهران، گروه فیزیولوژی ورزشی، تهران، ایران

2 دانشیار فیزیولوژی ورزشی، دانشکده تربیت بدنی دانشگاه خوارزمی تهران، گروه فیزیولوژی ورزشی، تهران، ایران

3 استاد فیزیولوژی پزشکی، دانشکده پزشکی دانشگاه علوم پزشکی جندی شاپور اهواز، گروه فیزیولوژی ، اهواز، ایران

4 استاد فیزیولوژی ورزشی، دانشکده تربیت بدنی دانشگاه خوارزمی تهران، گروه فیزیولوژی ورزشی، تهران، ایران

10.22118/jsmj.2018.158583.1530

چکیده

مقدمه: دیابت یکی از بیماریهای مهم متابولیکی بوده که از پیامدهای آن، اختلال در عملکرد اندوتلیال است و فعالیت ورزشی مناسب به عنوان راه کاری غیر دارویی توصیه می شود. بنابراین هدف از پژوهش حاضر، بررسی تاثیر تمرین هوازی تداومی بر سطح سرمی نیتریک اکساید، مقاومت به انسولین و برخی از پروفایل های لیپیدی در موش های صحرایی نر دیابتی می باشد.
مواد و روش ها: 60 سر موش صحرایی نر ویستار به صورت تصادفی به 6 گروه 10 تایی کنترل-سالم، شم، هوازی، هوازی + سالین، دیابت و دیابت + تمرین هوازی تقسیم شدند. دیابت با تزریق درون صفاقی نیکوتین آمید - استرپتوزوتوسین القا شد. آزمودنی ها به مدت 6 هفته و هر هفته 5 جلسه در هفته به تمرین رو نوارگردان پرداختند. 48 ساعت پس از آخرین جلسه تمرین، کشته و سپس سطوح گلوکز، انسولین، نیتریک اکساید، LDL، HDL، TG و کلسترول اندازه گیری شد. از آزمون واریانس یک طرفه برای تحلیل داده ها استفاده شد(p<0.05).
نتایج: القای دیابت موجب افزایش میزان گلوکز و مقاومت به انسولین و کاهش انسولین و نیتریک اکساید شد. پس از 6 هفته تمرین هوازی میزان گلوکز و مقاومت به انسولین کاهش و میزان نیتریک اکساید نسبت به گروه دیابت افزایش یافت. اما تاثیری بر سطح انسولین نداشت. همچنین 6 هفته تمرین هوازی تاثیر معناداری بر میزان فاکتورهای لیپیدی در گروه های مختلف نداشت (p<0.05).
نتیجه گیری: به نظر می رسد که تمرین هوازی می تواند با تاثیر بر عملکرد عروق اثر محافظتی در برابر بیماری های عروقی در بیماران دیابتی ایجاد کند.

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