مروری بر بوی بد دهان (هالیتوزیس)

نوع مقاله: مروری

نویسندگان

1 دانشیار گروه پریودنتولوژی.گروه پریودنتولوژی، دانشکده دندانپزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران.

2 دانشیار گروه پریودنتولوژی. گروه پریودنتولوژی، دانشکده دندانپزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران.

چکیده

بوی نامطبوعی که از نفس افراد ساطع می شود به هالیتوزیس مشهور است. علل بوی بد دهان به دو دسته داخل دهانی و خارج دهانی تقسیم بندی میشوند. حدود 85 درصد از موارد بوی بد دهان علتی در داخل دهان دارند و عمدتا" در اثر فعالیت میکروارگانیزم ها و تخریب و تجزیه آمینو اسیدها به گازهای بد بو ایجاد می­شوند. احتمالا" گونه های مختلف میکروبی در این فرایند نقش دارند و مرتبط با یک گونه بخصوص میکروبی نیست. در بین علل داخل دهانی زبان باردار و عفونت های پریودنتال نقش عمده ای دارند. در بین علل خارج دهانی، لوزه ها و بخصوص التهاب مزمن لوزه از علل شایع بوی بد دهان هستند. در این بررسی،اپیدمیولوژی، طبقه بندی، علل داخل دهانی و علل خارج دهانی بحث شده است. در پایان به روشهای مختلف تشخیص و گزینه های مختلف درمان پرداخته شده است.

کلیدواژه‌ها


 

1-Scully C. Halitosis. BMJ clinical evidence 2014; 2014.

2-Moemen M. Tohfeh Hakim Moemen. 1st ed. Tehran: Shahid Beheshti University of Medical Sciences Publisher; 2007.

3-Aimetti M, Perotto S, Castiglione A, Ercoli E, Romano F. Prevalence estimation of halitosis and its association with oral health-related parameters in an adult population of a city in North Italy. Journal of clinical periodontology 2015.

4-Akaji EA, Folaranmi N, Ashiwaju O. Halitosis: a review of the literature on its prevalence, impact and control. Oral health & preventive dentistry 2014; 12(4):297–304.

5-Bakhshaee M, Jabari F, Ghassemi MM, Hourzad S, Deutscher R, Nahid K. The prevalence of allergic rhinitis in patients with chronic rhinosinusitis. Iranian journal of otorhinolaryngology 2014; 26(77):245–249.

6-Hammad MM, Darwazeh AM, Al-Waeli H, Tarakji B, Alhadithy TT. Prevalence and awareness of halitosis in a sample of Jordanian population. Journal of International Society of Preventive & Community Dentistry 2014; 4(Suppl 3):86.

7-Kim SY, Sim S, Kim S-G, Park B, Choi HG. Prevalence and Associated Factors of Subjective Halitosis in Korean Adolescents. PloS one 2015; 10(10):e0140214.

8-Obeidat SR, Khabour OF, Alzoubi KH, Mahasneh AM, Bibars ARM, Khader YS et al. Prevalence, social acceptance, and awareness of waterpipe smoking among dental university students: a cross sectional survey conducted in Jordan. BMC research notes 2014; 7:832.

9-Villa A, Zollanvari A, Alterovitz G, Cagetti MG, Strohmenger L, Abati S. Prevalence of halitosis in children considering oral hygiene, gender and age. International journal of dental hygiene 2014; 12(3):208–212.

10-Aydin M, Harvey-Woodworth CN. Halitosis: a new definition and classification. British dental journal 2014; 217(1):E1.

11-Soares LG, Jonski G, Tinoco EMB, and Young A. Short-term effect of strontium- and zinc-containing toothpastes and mouthrinses on volatile sulphur compounds in morning breath: a randomized, double-blind, cross-over clinical study. European journal of oral sciences 2015; 123(2):72–79.

12-Oliveira-Neto JM, Sato S, Pedrazzi V. How to deal with morning bad breath: A randomized, crossover clinical trial. Journal of Indian Society of Periodontology 2013; 17(6):757–761.

13-van der Sluijs E, Slot DE, Bakker E, Van der Weijden, G A. The effect of water on morning bad breath: a randomized clinical trial. International journal of dental hygiene 2016; 14(2):124–134.

14-Setia S, Pannu P, Gambhir RS, Galhotra V, Ahluwalia P, Sofat A. Correlation of oral hygiene practices, smoking and oral health conditions with self perceived halitosis amongst undergraduate dental students. Journal of natural science, biology, and medicine 2014; 5(1):67–72.

15-Santos A, Pascual A, Llopis J, Giner L, Kim DM, Levi P JR et al. Self-reported Oral Hygiene Habits in Smokers and Nonsmokers Diagnosed with Periodontal Disease. Oral health & preventive dentistry 2015; 13(3):245–251.

16-Jiun ILE, Siddik, Siti Nur'Ain Abu Bakar, Malik SN, Tin-Oo MM, Alam MK, Khan MMH. Association between Oral Hygiene Status and Halitosis among Smokers and Nonsmokers. Oral health & preventive dentistry 2015; 13(5):395–405.

17-Erovic Ademovski S, Martensson C, Persson GR, Renvert S. The effect of periodontal therapy on intra-oral halitosis: a case series. Journal of clinical periodontology 2016; 43(5):445–452.

18-Lee S-H, Baek D-H. Effects of Streptococcus thermophilus on volatile sulfur compounds produced by Porphyromonas gingivalis. Archives of oral biology 2014; 59(11):1205–1210.

19-Calil CM, Oliveira GM, Cogo K, Pereira AC, Marcondes FK, Groppo FC. Effects of stress hormones on the production of volatile sulfur compounds by periodontopathogenic bacteria. Brazilian oral research 2014; 28.

20-Kato H, Yoshida A, Awano S, Ansai T, Takehara T. Quantitative detection of volatile sulfur compound- producing microorganisms in oral specimens using real-time PCR. Oral diseases 2005; 11 Suppl 1:67–71.

21-Morin M-P, Bedran TBL, Fournier-Larente J, Haas B, Azelmat J, Grenier D. Green tea extract and its major constituent epigallocatechin-3-gallate inhibit growth and halitosis-related properties of Solobacterium moorei. BMC complementary and alternative medicine 2015; 15:48.

22-Coulthwaite L, Verran J. Development of an in vitro denture plaque biofilm to model denture malodour. Journal of breath research 2008; 2(1):17004.

23-Ren W, Xun Z, Wang Z, Zhang Q, Liu X, Zheng H et al. Tongue Coating and the Salivary Microbial Communities Vary in Children with Halitosis. Scientific reports 2016; 6:24481.

24-Outhouse TL, Al-Alawi R, Fedorowicz Z, Keenan JV. WITHDRAWN: Tongue scraping for treating halitosis. The Cochrane database of systematic reviews 2016(5):CD005519.

25-Lee E-S, Yim H-K, Lee H-S, Choi J-H, Lee JH, Kim B-I. Clinical assessment of oral malodor using autofluorescence of tongue coating. Photodiagnosis and photodynamic therapy 2016; 13:323–329.

26-Kamaraj R D, Bhushan KS, K L V. An evaluation of microbial profile in halitosis with tongue coating using PCR (polymerase chain reaction) - a clinical and microbiological study. Journal of clinical and diagnostic research JCDR 2014; 8(1):263–267.

27-Hitz Lindenmuller I, Weiss P, Volken M, Filippi A. Diagnostics of tongue coating using autofluorescence. Swiss dental journal 2015; 125(10):1074.

28-Gurvits GE, Tan A. Black hairy tongue syndrome. World journal of gastroenterology 2014; 20(31):10845–10850.

29-          Habibagahi Z, Khorshidi H, Hekmati S. Periodontal Health Status among Patients with Behcet's Disease. Scientifica 2016; 2016:7506041.

30-Bolepalli AC, Munireddy C, Peruka S, Polepalle T, Choudary Alluri LS, Mishaeel S. Determining the association between oral malodor and periodontal disease: A case control study. Journal of International Society of Preventive & Community Dentistry 2015; 5(5):413–418.

31-          G Soares L, Castagna L, C Weyne S, G Silva D, E V Falabella M, M B Tinoco E. Effectiveness of full- and partial-mouth disinfection on halitosis in periodontal patients. Journal of oral science 2015; 57(1):1–6.

32-Geest S de, Laleman I, Teughels W, Dekeyser C, Quirynen M. Periodontal diseases as a source of halitosis: a review of the evidence and treatment approaches for dentists and dental hygienists. Periodontology 2000 2016; 71(1):213–227.

33-Iatropoulos A, Panis V, Mela E, Stefaniotis T, Madianos PN, and Papaioannou W. Changes of volatile sulphur compounds during therapy of a case series of patients with chronic periodontitis and halitosis. Journal of clinical periodontology 2016; 43(4):359–365.

34-Calil C, Liberato FL, Pereira AC, Castro Meneghim M de, Goodson JM, Groppo FC. The relationship between volatile sulphur compounds, tongue coating and periodontal disease. International journal of dental hygiene 2009; 7(4):251–255.

35-Kurata H, Awano S, Yoshida A, Ansai T, Takehara T. The prevalence of periodontopathogenic bacteria in saliva is linked to periodontal health status and oral malodour. Journal of medical microbiology 2008; 57(Pt 5):636–642.

36-Mantilla Gomez S, Danser MM, Sipos PM, Rowshani B, van der Velden U, Van der Weijden, G A. Tongue coating and salivary bacterial counts in healthy/gingivitis subjects and periodontitis patients. Journal of clinical periodontology 2001; 28(10):970–978.

37-Yaegaki K, Sanada K. Biochemical and clinical factors influencing oral malodor in periodontal patients. Journal of periodontology 1992; 63(9):783–789.

38-Milella L. The Negative Effects of Volatile Sulphur Compounds. Journal of veterinary dentistry 2015; 32(2):99–102.

39-          Tarakji B, Saleh LA, Umair A, Azzeghaiby SN, Hanouneh S. Systemic review of dry socket: aetiology, treatment, and prevention. Journal of clinical and diagnostic research JCDR 2015; 9(4):3.

40-Khorshidi H, Raoofi S, Moattari A, Bagheri A, Kalantari MH. In Vitro Evaluation of Bacterial Leakage at Implant-Abutment Connection: An 11-Degree Morse Taper Compared to a Butt Joint Connection. International journal of biomaterials 2016; 2016:8527849.

41-Tangerman A, Winkel EG. Extra-oral halitosis: an overview. Journal of breath research 2010; 4(1):17003.

42-Talebian A, Tazhibi M, Iranpoor R, Semyari H, Taherzadeh M. Relationship between tonsil odor and oral malodor: a clinical study on 48 Iranian patients. Journal of breath research 2008; 2(1):17016.

43-Ferguson M, Aydin M, Mickel J. Halitosis and the tonsils: a review of management. Otolaryngology--head and neck surgery official journal of American Academy of Otolaryngology-Head and Neck Surgery 2014; 151(4):567–574.

44-Ferguson M, Aydin M, Mickel J. Halitosis and the tonsils: a review of management. Otolaryngology--head and neck surgery official journal of American Academy of Otolaryngology-Head and Neck Surgery 2014; 151(4):567–574.

45-Ghabanchi J, Haghnegahdar A, Khojastehpour L, Ebrahimi A. Frequency of tonsilloliths in panoramic views of a selected population in southern iran. Journal of dentistry (Shiraz, Iran) 2015; 16(2):75–80.

46-Al-Abbasi AM. Tonsillectomy for the treatment of halitosis. Nigerian journal of medicine journal of the National Association of Resident Doctors of Nigeria 2009; 18(3):295–298.

47-Suzuki N, Yoneda M, Naito T, Iwamoto T, Masuo Y, Yamada K et al. Detection of Helicobacter pylori DNA in the saliva of patients complaining of halitosis. Journal of medical microbiology 2008; 57(Pt 12):1553–1559.

48-Tangerman A, Winkel EG, Laat L de, van Oijen AH, Boer WA de. Halitosis and Helicobacter pylori infection. Journal of breath research 2012; 6(1):17102.

49-Hoshi K, Yamano Y, Mitsunaga A, Shimizu S, Kagawa J, Ogiuchi H. Gastrointestinal diseases and halitosis: association of gastric Helicobacter pylori infection. International dental journal 2002; 52 Suppl 3:207–211.

50-HajiFattahi F, Hesari M, Zojaji H, Sarlati F. Relationship of Halitosis with Gastric Helicobacter Pylori Infection. Journal of dentistry (Tehran, Iran) 2015; 12(3):200–205.

51-Yilmaz AE, Bilici M, Tonbul A, Karabel M, Dogan G, Tas T. Paediatric Halitosis and Helicobacter pylori Infection. Journal of the College of Physicians and Surgeons--Pakistan JCPSP 2012; 22(1):27–30.

52-Chuang S-F, Sung J-M, Kuo S-C, Huang J-J, Lee S-Y. Oral and dental manifestations in diabetic and nondiabetic uremic patients receiving hemodialysis. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2005; 99(6):689–695.

53-          Murali P, Narasimhan M, Periasamy S, Harikrishnan TC. A comparison of oral and dental manifestations in diabetic and non-diabetic uremic patients receiving hemodialysis. Journal of oral and maxillofacial pathology JOMFP 2012; 16(3):374–379.

54-          Guglielmi M, Beushausen M, Feng C, Beech A, Baur D. Halitosis as a product of hepatic disease. SADJ journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging 2014; 69(8):364–367.

55-Gulsahi A, Evirgen S, Oztas B, Genc Y, Cetinel Y. Volatile sulphur compound levels and related factors in patients with chronic renal failure. Journal of clinical periodontology 2014; 41(8):814–819.

56-Hajian-Tilaki A, Oliae F, Jenabian N, Hajian-Tilaki K, Motallebnejad M. Oral health-related quality of life and periodontal and dental health status in Iranian hemodialysis patients. The journal of contemporary dental practice 2014; 15(4):482–490.

57-Mackay RJ, McEntyre CJ, Henderson C, Lever M, George PM. Trimethylaminuria: causes and diagnosis of a socially distressing condition. The Clinical biochemist. Reviews / Australian Association of Clinical Biochemists 2011; 32(1):33–43.

58-Messenger J, Clark S, Massick S, Bechtel M. A review of trimethylaminuria: (fish odor syndrome). The Journal of clinical and aesthetic dermatology 2013; 6(11):45–48.

59-Bascones-Martinez A, Munoz-Corcuera M, Bascones-Ilundain C. Side effects of drugs on the oral cavity. Medicina clinica 2015; 144(3):126–131.

60-Ueno M, Takeuchi S, Takehara S, Kawaguchi Y. Saliva viscosity as a potential risk factor for oral malodor. Acta odontologica Scandinavica 2014; 72(8):1005–1009.

61-Koshimune S, Awano S, Gohara K, Kurihara E, Ansai T, Takehara T. Low salivary flow and volatile sulfur compounds in mouth air. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2003; 96(1):38–41.

62-Cortelli JR, Barbosa MDS, Westphal MA. Halitosis: a review of associated factors and therapeutic approach. Brazilian oral research 2008; 22 Suppl 1:44–54.

63-Gurvits GE, Tan A. Black hairy tongue syndrome. World journal of gastroenterology 2014; 20(31):10845–10850.

64-Takahashi N. Oral Microbiome Metabolism: From "Who Are They?" to "What Are They Doing?” Journal of dental research 2015; 94(12):1628–1637.

65-Mokeem SA. Halitosis: a review of the etiologic factors and association with systemic conditions and its management. The journal of contemporary dental practice 2014; 15(6):806–811.

66-          Kursun S, Acar B, Atakan C, Oztas B, Paksoy CS. Relationship between genuine and pseudohalitosis and social anxiety disorder. Journal of oral rehabilitation 2014; 41(11):822–828.

67-Schmidt J, Krause F, Haak R. Halitosis: measurement in daily practice. Quintessence international (Berlin, Germany 1985) 2015; 46(7):633–641.

68-Greenman J, Lenton P, Seemann R, Nachnani S. Organoleptic assessment of halitosis for dental professionals--general recommendations. Journal of breath research 2014; 8(1):17102.

69-Laleman I, Dadamio J, Geest S de, Dekeyser C, Quirynen M. Instrumental assessment of halitosis for the general dental practitioner. Journal of breath research 2014; 8(1):17103.

70-Lee E-S, Yim H-K, Lee H-S, Choi J-H, Lee JH, Kim B-I. Clinical assessment of oral malodor using autofluorescence of tongue coating. Photodiagnosis and photodynamic therapy 2016; 13:323–329.

71-Tangerman A, Winkel EG. The portable gas chromatograph OralChroma: a method of choice to detect oral and extra-oral halitosis. Journal of breath research 2008; 2(1):17010.

72-Lee H-J, Kim HM, Kim N, Oh JC, Jo HJ, Lee J-T et al. Association between halitosis diagnosed by a questionnaire and halimeter and symptoms of gastroesophageal reflux disease. Journal of neurogastroenterology and motility 2014; 20(4):483–490.

73-wanicka-Grzegorek E, Michalik J, Kepa J, Wierzbicka M, Aleksinski M, Pierzynowska E. Subjective patients' opinion and evaluation of halitosis using halimeter and organoleptic scores. Oral diseases 2005; 11 Suppl 1:86–88.

74-Petrini M, Costacurta M, Ferrante M, Trentini P, Docimo R, Spoto G. Association between the organoleptic scores, oral condition and salivary beta-galactosidases in children affected by halitosis. International journal of dental hygiene 2014; 12(3):213–218.

75-Farrell S, Baker RA, Somogyi-Mann M, Witt JJ, Gerlach RW. Oral malodor reduction by a combination of chemotherapeutical and mechanical treatments. Clinical oral investigations 2006; 10(2):157–163.

76-Martinez RCR, Bedani R, Saad SMI. Scientific evidence for health effects attributed to the consumption of probiotics and prebiotics: an update for current perspectives and future challenges. The British journal of nutrition 2015; 114(12):1993–2015.

77-Pham TAV, Ueno M, Zaitsu T, Takehara S, Shinada K, Lam PH et al. Clinical trial of oral malodor treatment in patients with periodontal diseases. Journal of periodontal research 2011; 46(6):722–729.

78-Asokan S, Kumar RS, Emmadi P, Raghuraman R, Sivakumar N. Effect of oil pulling on halitosis and microorganisms causing halitosis: a randomized controlled pilot trial. Journal of the Indian Society of Pedodontics and Preventive Dentistry 2011; 29(2):90–94.

79-Saad S, Gomez-Pereira P, Hewett K, Horstman P, Patel J, Greenman J. Daily reduction of oral malodor with the use of a sonic tongue brush combined with an antibacterial tongue spray in a randomized cross-over clinical investigation. Journal of breath research 2016; 10(1):16013.

80-Dadamio J, van Tournout M, Teughels W, Dekeyser C, Coucke W, Quirynen M. Efficacy of different mouthrinse formulations in reducing oral malodour: a randomized clinical trial. Journal of clinical periodontology 2013; 40(5):505–513.

81-Erovic Ademovski S, Lingstrom P, Renvert S. The effect of different mouth rinse products on intra-oral halitosis. International journal of dental hygiene 2016; 14(2):117–123.

82-Fedorowicz Z, Aljufairi H, Nasser M, Outhouse TL, Pedrazzi V. Mouthrinses for the treatment of halitosis. The Cochrane database of systematic reviews 2008(4):CD006701.

83-Fedorowicz Z, Aljufairi H, Nasser M, Outhouse TL, Pedrazzi V. WITHDRAWN: Mouthrinses for the treatment of halitosis. The Cochrane database of systematic reviews 2016(5):CD006701.

84-Pedrazzi V, Do Nascimento C, Mardegan Issa JP, Fedorowicz Z. Interventions for managing halitosis.

85-Rosenberg M, Gelernter I, Barki M, Bar-Ness R. Day-long reduction of oral malodor by a two-phase oil: water mouthrinse as compared to chlorhexidine and placebo rinses. Journal of periodontology 1992; 63(1):39–43.

86-Kang JH, Jang YJ, Kim DJ, Park JW. Antimicrobial effectiveness of cetylpyridinium chloride and zinc chloride-containing mouthrinses on bacteria of halitosis and peri-implant disease. The International journal of oral & maxillofacial implants 2015; 30(6):1341–1347.

87-Roldan S, Winkel EG, Herrera D, Sanz M, van Winkelhoff AJ. The effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc lactate on the microflora of oral halitosis patients: a dual-centre, double-blind placebo-controlled study. Journal of clinical periodontology 2003; 30(5):427–434.

88-Saad S, Greenman J, Shaw H. Comparative effects of various commercially available mouthrinse formulations on oral malodor. Oral diseases 2011; 17(2):180–186.

89-Haerian-Ardakani A, Rezaei M, Talebi-Ardakani M, Keshavarz Valian N, Amid R, Meimandi M et al. Comparison of Antimicrobial Effects of Three Different Mouthwashes. Iranian journal of public health 2015; 44(7):997–1003.

90-Kim J-S, Park J-W, Kim D-J, Kim Y-K, Lee J-Y. Direct effect of chlorine dioxide, zinc chloride and chlorhexidine solution on the gaseous volatile sulfur compounds. Acta odontologica Scandinavica 2014; 72(8):645–650.

91-Sreenivasan PK, Gittins E. The effects of a chlorhexidine mouthrinse on culturable microorganisms of the tongue and saliva. Microbiological research 2004; 159(4):365–370.

92-Malhotra R, Grover V, Kapoor A, Saxena D. Comparison of the effectiveness of a commercially available herbal mouthrinse with chlorhexidine gluconate at the clinical and patient level. Journal of Indian Society of Periodontology 2011; 15(4):349–352.

93-Mishra V, Shettar L, Bajaj M, Math AS. Comparison of a commercially available herbal and 0.2% chlorhexidine mouthrinse for prevention of oral malodor: A clinical trial. Journal of International Society of Preventive & Community Dentistry 2016; 6(Suppl 1):S6-S11.

94-Yadav SR, Kini VV, Padhye A. Inhibition of Tongue Coat and Dental Plaque Formation by Stabilized Chlorine Dioxide Vs Chlorhexidine Mouthrinse: A Randomized, Triple Blinded Study. Journal of clinical and diagnostic research JCDR 2015; 9(9):74.

95-Sreenivasan PK, Haraszthy VI, Zambon JJ. Antimicrobial efficacy of 0.05% cetylpyridinium chloride mouthrinses. Letters in applied microbiology 2013; 56(1):14–20.

96-Fine DH. Listerine: past, present and future--a test of thyme. Journal of dentistry 2010; 38 Suppl 1:5.

97-Ghabanchi J, Moattari A, Darafshi R, Andisheh Tadbir A, Khorshidi H, Shakib M. Effects of three Commercial Mouth Rinses on the Cultured Fibroblasts: An in Vitro Study. Journal of dentistry (Shiraz, Iran) 2013; 14(2):64–67.

98-Akhtar J, Siddique KM, Bi S, Mujeeb M. A review on phytochemical and pharmacological investigations of miswak (Salvadora persica Linn). Journal of pharmacy & bioallied sciences 2011; 3(1):113–117.

99-Mohamed SA, Khan JA. Antioxidant capacity of chewing stick miswak Salvadora persica. BMC complementary and alternative medicine 2013; 13:40.

100-Darvishi Khezri H, Haidari Gorji MA, Morad A, and Gorji H. Comparison of the antibacterial effects of matrica & Persica and chlorhexidine gluconate mouthwashes in mechanically ventilated ICU patients: a double blind randomized clinical trial. Revista chilena de infectologia organo oficial de la Sociedad Chilena de Infectologia 2013; 30(4):361–373.

101-Kappler U, Schafer H. Transformations of dimethylsulfide. Metal ions in life sciences 2014; 14:279–313.

102-Grigor J, Roberts AJ. Reduction in the levels of oral malodor precursors by hydrogen peroxide: in-vitro and in-vivo assessments. The Journal of clinical dentistry 1992; 3(4):111–115.

103-Shinada K, Ueno M, Konishi C, Takehara S, Yokoyama S, Zaitsu T et al. Effects of a mouthwash with chlorine dioxide on oral malodor and salivary bacteria: a randomized placebo-controlled 7-day trial. Trials 2010; 11:14.

104-Yadav SR, Kini VV, Padhye A. Inhibition of Tongue Coat and Dental Plaque Formation by Stabilized Chlorine Dioxide Vs Chlorhexidine Mouthrinse: A Randomized, Triple Blinded Study. Journal of clinical and diagnostic research JCDR 2015; 9(9):74.

105-Kim J-S, Park J-W, Kim D-J, Kim Y-K, Lee J-Y. Direct effect of chlorine dioxide, zinc chloride and chlorhexidine solution on the gaseous volatile sulfur compounds. Acta odontologica Scandinavica 2014; 72(8):645–650.

106-Mendes L, Coimbra J, Pereira A, Resende M, Pinto M. Comparative effect of a new mouthrinse containing chlorhexidine, triclosan and zinc on volatile sulphur compounds: a randomized, crossover, double-blind study. International journal of dental hygiene 2015.

107-Thrane PS, Young A, Jonski G, Rolla G. A new mouthrinse combining zinc and chlorhexidine in low concentrations provides superior efficacy against halitosis compared to existing formulations: a double-blind clinical study. The Journal of clinical dentistry 2007; 18(3):82–86.

108-Winkel EG, Roldan S, van Winkelhoff AJ, Herrera D, Sanz M. Clinical effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc-lactate on oral halitosis. A dual-center, double-blind placebo-controlled study. Journal of clinical periodontology 2003; 30(4):300–306.

109-Young A, Jonski G, Rolla G. Combined effect of zinc ions and cationic antibacterial agents on intraoral volatile sulphur compounds (VSC). International dental journal 2003; 53(4):237–242.

110-Luca-Monasterios F de, Chimenos-Kustner E, Lopez-Lopez J. Effect of chewing gum on halitosis. Medicina clinica 2014; 143(2):64–67.

111-Shiyao L, Yamei X, Deyu H. Anti-halitosis effect of sugar-free chewing gum. Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 2015; 33(2):166–168.

112-Tian M, Hanley AB, Dodds MWJ, Yaegaki K. Chewing gum containing allyl isothiocyanate from mustard seed extract is effective in reducing volatile sulfur compounds responsible for oral malodor. American journal of dentistry 2013; 26(4):180–184.

113-Linka WA, Golenia E, Zgoda MM, Kolodziejczyk MK. The use of semi-synthetic polymers in the formulation of sucking and chewable tablets containing sage extract and zinc gluconate. Polimery w medycynie 2014; 44(4):237–245.

114-Hashiba T, Takeuchi K, Shimazaki Y, Takeshita T, Yamashita Y. Chewing xylitol gum improves self-rated and objective indicators of oral health status under conditions interrupting regular oral hygiene. The Tohoku journal of experimental medicine 2015; 235(1):39–46.

115-Haghgoo R, Abbasi F. Evaluation of the use of a peppermint mouth rinse for halitosis by girls studying in Tehran high schools. Journal of International Society of Preventive & Community Dentistry 2013; 3(1):29–31.

116-Sterer N, Ovadia O, Weiss EI, Perez Davidi M. Day-long reduction of oral malodor by a palatal mucoadhesive tablet containing herbal formulation. Journal of breath research 2013; 7(2):26004.

117-Tatikonda A, Debnath S, Chauhan VS, Chaurasia VR, Taranath M, Sharma AM. Effects of herbal and non-herbal toothpastes on plaque and gingivitis: A clinical comparative study. Journal of International Society of Preventive & Community Dentistry 2014; 4(Suppl 2):9.

118-Suzuki M, Hayama K, Takahashi M, Ezawa K, Yamazaki M, Matsukawa T et al. The effects of an aroma candy on oral Candida albicans colony-forming units (CFU) and oral hygiene states in healthy elderly carrying Candida albicans. Medical mycology journal 2015; 56(1):40.

119-Dragich AM, Halpern BP. An oral-cavity component in retronasal smelling of natural extracts. Physiology & behavior 2008; 93(3):521–528.

120-Lodhia P, Yaegaki K, Khakbaznejad A, Imai T, Sato T, and Tanaka T et al. Effect of green tea on volatile sulfur compounds in mouth air. Journal of nutritional science and vitaminology 2008; 54(1):89–94.