نانولیپوزوم ها به عنوان حامل های دارورسان جدید

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشیار فارماسیوتیکس، مرکز تحقیقات فناوری نانو، دانشگاه علوم پزشکی جندی شاپور اهواز، ایران.

2 دانشجوی دکتری عمومی داروسازی، مرکز تحقیقات فناوری نانو، دانشگاه علوم پزشکی جندی شاپور اهواز، ایران.

چکیده

نانولیپوزوم ها ساختارهای کلوئیدی متشکل از یک غشای دو لایه هستند. در محلول های آبی گروه های آبگریز فسفولیپید به سمت داخل کره و گروهای آب دوستشان به سمت خارج کره جهت گیری می کنند. در نتیجه یک غشاء کروی کاملا بسته تشکیل شده از دولایه مولکولهای چربی بوجود می آید. امروزه این نانوساختارها به عنوان حامل های رسانش دارو، ژن و همچنین مدلسازی غشاهای سلولی چه در حیوان و چه در انسان مورد استفاده قرار می گیرند. توانایی این نانوساختارها در کپسوله نمودن مقدار زیاد دارو، به حداقل رساندن عوارض جانبی ناخواسته، اثربخشی بالا و سمیت پایین توانسته علاقه محققین را به آن جلب کند. محققین حمل داروهای ضد سرطان توسط این نانوحامل­ها را مورد بررسی قرار داده­اند. نتایج این تحقیقات نشان داده است که با استفاده از نانولیپوزوم­ها، دارورسانی به سلول­های هدف بهبود یافته و اثربخشی داروها افزایش یافته است. در این مقاله مروری سعی شده علاوه بر معرفی اجمالی این نانوساختارها، به روش های متنوع ساخت آنها و همچنین کاربرد آنها به عنوان حامل های دارورسان پرداخته شود.

کلیدواژه‌ها


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